Administration of cortisone with Hyaluronic Acid has a Chondroprotective Effect

Joint administration of cortisone with hyaluronic acid has a chondroprotective effect

The cartilage-damaging effects of cortisone Should through the Combination with hyaluronic acid be attenuated. Experimental studies and initial clinical results suggest a promising treatment option for treatment of knee osteoarthritis.

Intra-articular infiltrations are a cornerstone of conservative treatment of knee osteoarthritis. Commonly administered substances are local anesthetics, cortisone and hyaluronic acid. Local anesthetics are often used as they provide immediate pain relief. However, numerous studies have shown damage to cartilage cells, even after a single infiltration. Cortisone has a potent anti-inflammatory effect and antagonizes the inflammatory state of osteoarthritis. However, studies have shown that cortisone proapoptotic effects (= programmed cell death) on cartilage cells.

As a viscosupplement, hyaluronic acid leads to a Improving gliding properties of cartilage and also stimulates the body's own production of hyaluronic acid. In addition, a certain anti-inflammatory effect of hyaluronic acid is known. In clinical practice, local anesthetics are most commonly administered together with cortisone.

The positive effects of this joint administration (pain relief, anti-inflammation) are contrasted with the well-known negative cartilage-damaging effects of both substances. In recent years, a joint Administration of cortisone with hyaluronic acid carried out. The aim is to reduce the positive effects of cortisone (Anti-inflammation) with the positive effects of hyaluronic acid (viscosupplementation) to combine. At the same time, the cartilage-damaging effects of cortisone should be attenuated by hyaluronic acid.

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